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PubMed · 6778607

Screening trial with the coordinated gold compound auranofin using mouse lymphocyte leukemia P388.

T M Simon·D H Kunishima·G J Vibert·A Lorber
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Abstract

The coordinated gold compound, 2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranosato-S-triethylphosphine-gold (auranofin) was found to be effective in increasing the life span of C57BL x DBA/2 F1 mice inoculated with the lymphocytic leukemia P388. A number of dose schedules were used, the lowest dose being 6 mg/kg every fourth day and the highest dose being 6.0 mg/kg twice daily for 9 days; the lowest and highest doses produced treated versus control ratios of 140 and 220%, respectively. All treatment groups achieved the minimum treated versus control ratio of 125%. Animal weights remained stable at twice-daily and high-dose-daily regimens. Increased life span and weight changes were both found to correlate with drug concentration and/or dose frequency.

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AnimalsAntineoplastic AgentsAuranofinAurothioglucoseBody WeightDrug Evaluation, PreclinicalGoldLeukemia, ExperimentalLeukemia, LymphoidMicePhosphinesJournal Article

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T M Simon, D H Kunishima, G J Vibert, A Lorber. 1981. Screening trial with the coordinated gold compound auranofin using mouse lymphocyte leukemia P388.. https://pubmed.ncbi.nlm.nih.gov/6778607/

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