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PubMed · 6782378

Amyloid typing using antisera to prototype fibril proteins. A brief note.

R P Linke
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Abstract

Amyloid fibril proteins from three patients with generalized amyloidosis were isolated and chemically characterized by N-terminal amino-acid sequence studies in two of them. As they belonged to three different amyloid classes they served as prototypes for the preparation of antisera specific for each class. Using these antisera in immunodiffusion, amyloid fibril proteins of 15 additional cases with generalized amyloidosis have been investigated. These could be grouped into four categories: seven belonging to the amyloid A type, three to the amyloid L, lambda type, and three to the amyloid L, kappa type; the amyloid fibril proteins of two patients could not be classified by these agents and may represent still unidentified amyloid types.

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AmyloidAmyloidosisChemical PhenomenaChemistryHumansImmunodiffusionImmunoglobulin kappa-ChainsImmunoglobulin lambda-ChainsJournal ArticleResearch Support, Non-U.S. Gov't

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R P Linke. Amyloid typing using antisera to prototype fibril proteins. A brief note.. https://doi.org/10.1016/0047-6374(80)90118-9

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