Hypercoagulation in glomerulonephritis.

H H Salem; J A Whitworth; J Koutts; P S Kincaid-Smith; B G Firkin

doi:10.1136/bmj.282.6282.2083

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Hypercoagulation in glomerulonephritis.

H H Salem·J A Whitworth·J Koutts·P S Kincaid-Smith·B G Firkin

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Abstract

The clotting values of 50 patients with glomerulonephritis were examined. Three different coagulation groups were recognised: those with normal clotting values (group 1); those with high concentrations of factor VIII but otherwise normal clotting results (group 2); and patients who showed the presence of an activator of the intrinsic coagulation pathway, indicated by the presence of a short activated partial thromboplastin time or the ability of patients' plasma to shorten control clotting time in mixing studies (group 3). Patients in group 2 either had a uniform rise in all three components of the factor VIII molecule or a disproportionately higher concentration of factor-VIII-related antigen. In contrast, the level of VIII clotting activity in patients in group 3 was always higher than concentrations of either VIIIAg or VIIIWF. A significantly high incidence of thrombotic complications was observed in patients with group 3 but in none of the patients in either group 1 or group 2. Impaired renal function was more common in patients in groups 2 and 3, with higher mean serum creatinine concentrations in those with group 3. Patients with glomerulonephritis who have a short partial thromboplastin time with kaolin or who shorten control clotting time form a subgroup in whom hypercoagulation could adversely affect the course of their disease. The value of antiplatelet or anticoagulant treatment in these patients needs to be explored.

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Adolescent Adult Aged Blood Coagulation Child Creatinine Factor VIII Female Glomerulonephritis Humans Male Middle Aged Partial Thromboplastin Time Thrombosis Journal Article Research Support, Non-U.S. Gov't

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H H Salem, J A Whitworth, J Koutts, P S Kincaid-Smith, B G Firkin. 1981-06-27. Hypercoagulation in glomerulonephritis.. https://doi.org/10.1136/bmj.282.6282.2083

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