Gestational caffeine modifies offspring behaviour in mice.

C M Sinton; J L Valatx; M Jouvet

doi:10.1007/bf00433505

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Gestational caffeine modifies offspring behaviour in mice.

C M Sinton·J L Valatx·M Jouvet

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Abstract

Dams from two strains of mice, BALB/c C57BR were tested during gestation with caffeine, at doses of about 60, 80 and 100 mg/kg/day, in their drinking water. The resulting offspring were behaviourally tested over a 6-month period commencing at age 9 months. When compared with controls, mice from dams that had received caffeine demonstrated longer latencies in a passive avoidance test, and differences were also noted for female C57BR offspring in activity and habituation measures. Having controlled as far as possible for post-natal maternal and environmental effects, the most likely conclusion is that caffeine has a direct pharmacological action on the foetus, and should therefore be classed as a behavioural teratogen in mice.

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Animals Avoidance Learning Behavior, Animal Caffeine Dextroamphetamine Dopamine Female Male Mice Mice, Inbred BALB C Mice, Inbred Strains Motor Activity Pregnancy Prenatal Exposure Delayed Effects Reaction Time Sex Factors Journal Article Research Support, Non-U.S. Gov't

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C M Sinton, J L Valatx, M Jouvet. 1981. Gestational caffeine modifies offspring behaviour in mice.. https://doi.org/10.1007/bf00433505

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