Structure of a copper-isoniazid complex.

J C Hanson; N Camerman; A Camerman

doi:10.1021/jm00143a021

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Structure of a copper-isoniazid complex.

J C Hanson·N Camerman·A Camerman

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Abstract

It is well-known that complex formation with copper ions increases the in vitro mycobactericidal action of the antituberculosis agent isoniazid. We report here the preparation and structure of a copper(II)-isoniazid complex. Unit cell parameters are a = 9.575, b = 14.855, and c = 7.056 A and space group P2(1)2(1)2(1). Copper bonding geometry is square planar with the isoniazid carbonyl oxygen and hydrazide amino nitrogen atoms and two chlorines occupying coordination positions. Complexing with copper(II) does not significantly alter the isoniazid molecular conformation.

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Chemical Phenomena Chemistry Copper Crystallography Isoniazid Models, Molecular Molecular Conformation Mycobacterium tuberculosis Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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J C Hanson, N Camerman, A Camerman. 1981. Structure of a copper-isoniazid complex.. https://doi.org/10.1021/jm00143a021

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