PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 6798554

[Sodium valproate, platelet dysfunction and bleeding (author's transl)].

P Loiseau
View original source ↗Export metadata ↓

Abstract

Haemorrhagic tendencies, thrombocytopenia and/or platelet dysfunction have been reported in patients under sodium valproate (VPA) treatment for epilepsy. The true incidence and significance of these side-effects are discussed in the present paper based on case reports and systematic enquiries. The following conclusions emerge: VPA is responsible for thrombocytopenia and platelet dysfunction. These side-effects are dose-related, and the daily dosage should never exceed 40 mg/kg. Their mechanism is obscure and several explanations have been put forward. The effects of VPA on blood platelets may be considered as idiosyncratic in nature and have little clinical relevance unless patients contract an infectious disease or require surgery; only in such cases would a coagulation study be required.

Explore related subjects

Blood Platelet DisordersEpilepsyHumansThrombocytopeniaValproic AcidEnglish AbstractJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

P Loiseau. 1981-12-19. [Sodium valproate, platelet dysfunction and bleeding (author's transl)].. https://pubmed.ncbi.nlm.nih.gov/6798554/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2006

[Differential diagnosis of platelet disorders].

Platelet disorders frequently represent a cause of bleeding disorders with a late manifestation and spontaneous bleeding. Disturbances of cellular hemostasis can be of quantitative nature due to an altered production or destruction of platelets. Qualitative disturbances can be associated with defects of adhesion, secretion or degranulation. Drug induced reactions, inflammatory processes and autoimmune reactions are the most frequent underlying disorders. Even a late manifestation, however, does not exclude congenital disorders. In the differential diagnosis of thrombocyte disorders the anamnestic analysis of the clinical circumstances of manifestation, of a family background and potentially interfering drugs are of central importance. Template bleeding time, aggregometry and flow cytometry are complementary methods for the characterization of functional defects. First of all, a von Willebrand syndrome as the most frequent congenital form of a mucocutaneous bleeding pattern needs to be excluded. The clinical context is very important in the analysis of disturbances of platelet turnover. Reticulated platelets allow the quantitative assessment of reduced production or increased destruction. Platelet indices, morphological assessment of blood and bone marrow and immunological tests allow the pathogenetical classification of thrombocytopenia. Idiopathic thrombocytopenia (ITP) is a frequent diagnosis by exclusion. The analysis of glycoprotein expression and the genetic characterization of suspected congenital defects are only performed in selected cases. Clinical and laboratory assessment are complementary in the discrimination of secondary forms of thrombosis from clinically relevant clonal disturbances.

Blood Platelet Disorders↗