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Quantitative liver functions after 70% hepatectomy.

S I Yildirim·H E Poulsen
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Abstract

Following 70% hepatectomy on rats the galactose elimination capacity, taken as a measure of the cytosolic liver function, was reduced from 2.55 +/- 0.48 to 1.27 +/- 0.19 (mean +/- SEM) mumol/min. Six hours later it was restored to control values. The prothrombin index, representing the function of the endoplasmic reticulum, was reduced from 1.13 +/- 0.02 to 0.34 +/- 0.02 (arbitrary units) after 12 h, and it was restored after 96 h. The rapid normalization of the initial fall in the capacity to metabolize galactose reflects a two- to three-fold increase of the galactose metabolizing capacity of the remaining liver. This study demonstrates that liver functions are dissociated in time following 70% hepatectomy in the rat, and that the galactose elimination capacity is restored before regeneration can compensate for the loss in liver cell mass.

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AnimalsCytosolFemaleGalactoseHepatectomyLiverLiver RegenerationMicrosomes, LiverProthrombinRatsRats, Inbred StrainsTime FactorsJournal ArticleResearch Support, Non-U.S. Gov't

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BibTeXRIS

S I Yildirim, H E Poulsen. 1981. Quantitative liver functions after 70% hepatectomy.. https://doi.org/10.1111/j.1365-2362.1981.tb02015.x

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