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Allotypes in Basilea rabbits.

S Weiss·I Garcia·J C Jaton·A S Kelus
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Abstract

Basilea rabbits produce immunoglobulin molecules, practically all of which have lambda light chains rather than kappa chains. This variant strain was derived form a homozygous (b9/b9) male. Sensitive serological methods revealed that at least some homozygous bas/bas individuals possess traces (about 100 ng/ml) of b9 molecules. This level usually increases to almost 1 microgram/ml upon hyperimmunization with pneumococcal or streptococcal vaccines. One exceptional rabbit, with 50 micrograms/ml of b9 molecules, was found. In spite of the presence of b9 molecules in early pre-immune bleeds, homozygous bas/bas rabbits produce strong anti-b9 antibodies; i.e., they are capable of making autoantibodies. These anti-b9 allotypic antisera were not distinguishable by our methods from routinely produced anti-b9.

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AnimalsAntibody FormationFemaleHomozygoteImmunoglobulin AllotypesImmunoglobulin Light ChainsImmunoglobulin kappa-ChainsImmunoglobulin lambda-ChainsMalePedigreeRabbitsJournal ArticleResearch Support, Non-U.S. Gov't

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S Weiss, I Garcia, J C Jaton, A S Kelus. 1982. Allotypes in Basilea rabbits.. https://doi.org/10.1002/eji.1830120213

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