Biochemical evidence for multiple Ia molecules.

C S David; W P Lafuse; M Pierres

doi:10.1007/978-1-4684-4394-3_62

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Biochemical evidence for multiple Ia molecules.

C S David·W P Lafuse·M Pierres

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Abstract

Sequential immunoprecipitation and isoelectric focusing studies using anti-Ia monoclonal antibodies have shown multiple I-A and I-E Ia molecules. These studies suggest that the genes coding for Ia polypeptide chains A alpha, A beta, E beta and E alpha might have undergone further duplication and mutated. This would explain the diversity seen with Ia molecules in their ability to "present" numerous self and non-self antigens for generation of immune response.

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Animals Antibodies, Monoclonal Antigen-Antibody Complex Cross Reactions Genes, MHC Class II Histocompatibility Antigens Class II Isoantibodies Major Histocompatibility Complex Mice Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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C S David, W P Lafuse, M Pierres. 1982. Biochemical evidence for multiple Ia molecules.. https://doi.org/10.1007/978-1-4684-4394-3_62

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