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PubMed · 6820889

[Experimental study on local immunochemotherapy].

M Kasuga·M Sakita·T Yamane·T Torii·H Imai·N Kageyama·Y Fujita·S Majima
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Abstract

The purposes of this work were twofold: firstly to determine whether intratumor chemoimmunotherapy was more effective than either treatment alone or systemic therapy and; secondly to study how the intratumor therapy affected on the development of the tumor-specific immunity. Inbred male C3H/He mice and mouse ascited hepatoma 134 (MH 134) of C3H origin were used as host-tumor system. Mitomycin C was used as the chemotherapeutic agent and BCG as the immunopotentiating agent. Intratumor treatment of MMC + BCG led to complete cure in 85 percent of the mice. The lymph node metastases were markedly inhibited in the group treated with MMC + BCG compared to the groups treated with MMC alone or BCG alone. The growth of rechallenged tumor was investigated; 79% of mice treated with MMC + BCG were immune to rechallenge, whereas 57% of mice treated with BCG alone. The number of PFC and DTH against SRBC of the mice treated with MMC intraperitoneally significantly decreased compared to that treated with MMC intratumorally.

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AnimalsAntibiotics, AntineoplasticBCG VaccineHemolytic Plaque TechniqueHypersensitivity, DelayedLymphatic MetastasisMiceMice, Inbred C3HMitomycinMitomycinsNeoplasms, ExperimentalEnglish AbstractJournal Article

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M Kasuga, M Sakita, T Yamane, T Torii, H Imai, N Kageyama, Y Fujita, S Majima. 1982. [Experimental study on local immunochemotherapy].. https://pubmed.ncbi.nlm.nih.gov/6820889/

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