New antihypertensive cannabinoids.

H E Zaugg; J Kyncl

doi:10.1021/jm00356a017

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New antihypertensive cannabinoids.

H E Zaugg·J Kyncl

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Abstract

A number of azacannabinoids containing hydroxyacyl and aminoacetyl substituents on the nitrogen atom were synthesized. The hydroxyacetyl and gamma-hydroxybutyryl derivatives were potent antihypertensive agents (minimum effective dose, 3-5 mg/kg, orally) of the same order of activity as the highly CNS-active N-propargyl derivatives Ia and Ib. Furthermore, 4a showed weak stimulant properties at hypotensive dose levels, in contrast to the strongly CNS-depressant action characteristic of the N-propargyl analogues.

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Animals Antihypertensive Agents Blood Pressure Cannabinoids Heart Rate Hypertension Indicators and Reagents Magnetic Resonance Spectroscopy Rats Structure-Activity Relationship Comparative Study Journal Article

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H E Zaugg, J Kyncl. 1983. New antihypertensive cannabinoids.. https://doi.org/10.1021/jm00356a017

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