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Free estradiol increase with concomitant decrease of free testosterone in plasma from normal men after incubation with spironolactone.

P Biffignandi·C Massucchetti·G M Molinatti
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EstradiolHumansIn Vitro TechniquesMalePlasmaSpironolactoneTestosteroneJournal ArticleResearch Support, Non-U.S. Gov't

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P Biffignandi, C Massucchetti, G M Molinatti. 1983. Free estradiol increase with concomitant decrease of free testosterone in plasma from normal men after incubation with spironolactone.. https://doi.org/10.1055/s-2007-1018629

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PubMed1998

[Assessment of selected hormonal parameters in patients with mastopathy in postmenopausal period].

There have been assessed selected hormonal parameters in patients with mastopathy in postmenopausal period. The hormonal evaluation showed significantly higher mean concentration of prolactin in blood serum of patients with mastopathy than in the blood serum of healthy women. There was not functional hyperprolactinaemia in the patients in postmenopausal period. In the examined patients in postmenopausal age, there was revealed significantly higher mean concentration of oestradiol in blood serum, in comparison with the healthy women. There was also found significantly lower mean concentration of follicle-stimulating and luteotrophic hormones, which is probably due to enhanced inhibition of gonadotrophic hormones secretion by prolactin and oestradiol. The results of the conducted hormonal examinations suggest that prolactin is an agent, which produces mastopatial changes in women. Furthermore, it seems that genesis of mastopathy in postmenopausal period may be connected not only with disprolactinaemia but also with persistent oestrogenic activity. It should be thus admitted that hormonal examinations (with particular consideration given to prolactin) are appropriate management in diagnosis and treatment of patients with mastopathy.

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