Systemic apomorphine reverses intrastriatal dopamine-induced contralateral deviation.

J N Joyce; R E Davis; C Van Hartesveldt

doi:10.1016/0014-2999(83)90339-4

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Systemic apomorphine reverses intrastriatal dopamine-induced contralateral deviation.

J N Joyce·R E Davis·C Van Hartesveldt

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Abstract

Contralateral deviation induced by unilateral injection of 25 micrograms or 100 micrograms dopamine into the dorsal CPU was reversed to ipsilateral deviation by apomorphine administered systemically (1 mg/kg s.c.) before, at the same time, or after the dopamine. Contralateral deviation to a unilateral intrastriatal injection of 6.25 micrograms apomorphine was also reversed to ipsilateral deviation by systemically administered apomorphine. No significant effects on postural deviation were found when a control solution was injected unilaterally into the striatum, followed by systemic apomorphine. Contralateral deviation to the unilateral intrastriatal dopamine injection continued following a further bilateral intrastriatal injection of either dopamine or apomorphine. These results suggest that intrastriatal dopamine indirectly affects sites receptive to dopamine outside the striatum.

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Animals Apomorphine Corpus Striatum Dopamine Dopamine Antagonists Injections Male Motor Activity Rats Time Factors Journal Article

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J N Joyce, R E Davis, C Van Hartesveldt. 1983-02-18. Systemic apomorphine reverses intrastriatal dopamine-induced contralateral deviation.. https://doi.org/10.1016/0014-2999(83)90339-4

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