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PubMed · 6847210

Topical fluocinonide and tachyphylaxis.

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T P Senter. 1983. Topical fluocinonide and tachyphylaxis.. https://pubmed.ncbi.nlm.nih.gov/6847210/

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[Fluocinolone Acetonide Reference Standard (Control 981) of National Institute of Health Sciences].

The raw material of fluocinolone acetonide was examined for preparation of the "Fluocinolone Acetonide Reference Standard (Control 981)". The analytical data obtained were: melting point, 271.5 degree C; UV spectrum, Lambda max of 237.0 nm and specific absorbance in ethanol at 237 nm of 359.3; IR spectrum, same as that of the Fluocinolone Acetonide Reference Standard (Control 904); optical rotation, [alpha]20(D) = + 102.8; thin-layer chromatography, no impurities detected; high-performance liquid chromatography, one impurity detected and total amount estimated to be about 0.17%; loss on drying, 0.29%; assay by HPLC, 100.9%. Based on the above results, the raw material was authorized as the Fluocinolone Acetonide Reference Standard (Control 981) of the National Institute of Health Sciences.

Fluocinolone Acetonide↗