Does neurotoxic conditioning accelerate nerve regeneration?

A B Sterman

doi:10.1016/0014-4886(83)90321-7

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PubMed · 6852164

Does neurotoxic conditioning accelerate nerve regeneration?

A B Sterman

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Abstract

The prototype environmental neurotoxin, 2,5-hexanedione (2,5-HD), induces changes in somata of sensory ganglia that are morphologically similar to chromatolysis: this study assessed the functional significance of neuronal alterations. Experimental rats were exposed 6 weeks to 2,5-HD, and after 1 week without treatment were then subjected to experimental crush of the sciatic nerve (paired controls were unintoxicated). Nerve regeneration was assayed by the pinch test 4 to 13 days after crush. These preliminary results did not show an accelerated rate of axonal outgrowth; however, there was a small but significant (P less than 0.05) decrease in the initial delay.

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Animals Axons Conditioning, Psychological Female Hexanones Ketones Nerve Crush Nerve Degeneration Nerve Regeneration Rats Rats, Inbred Strains Schwann Cells Sciatic Nerve Journal Article Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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A B Sterman. 1983. Does neurotoxic conditioning accelerate nerve regeneration?. https://doi.org/10.1016/0014-4886(83)90321-7

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