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PubMed · 6861879

Temperature-sensitive conformational changes in membrane-bound and solubilized [3H]imipramine binding sites.

A Davis·J M Morris·S W Tang
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Abstract

[3H]Imipramine binding sites are located on serotonergic nerve terminals and on blood platelets. Previous studies on our laboratories have indicated temperature-sensitive conformational changes in [3H]imipramine binding sites in hippocampal and cerebral cortex membranes. We now report that similar changes are observed in both membrane-bound and digitonin-solubilized [3H]imipramine binding sites of human blood platelets. This may indicate integrity of the solubilized binding site.

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AnimalsBinding SitesBlood PlateletsBrainHumansImipramineIn Vitro TechniquesProtein ConformationRatsSolubilityTemperatureTritiumJournal ArticleResearch Support, Non-U.S. Gov't

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A Davis, J M Morris, S W Tang. 1983-04-08. Temperature-sensitive conformational changes in membrane-bound and solubilized [3H]imipramine binding sites.. https://doi.org/10.1016/0014-2999(83)90595-2

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