Angiotensinogen.

D A Tewksbury

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PubMed · 6862036

Angiotensinogen.

D A Tewksbury

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Abstract

Human angiotensinogen has been purified from outdated blood bank plasma. The purified angiotensinogen has a specific angiotensin I (Ang I) content of 20.7 micrograms Ang I/mg protein and contains only one amino-terminal amino acid, aspartic acid. However, it exhibits two bands on sodium dodecyl sulfate-polyacrylamide gel electrophoresis with apparent molecular weights of 61,400 and 65,400. It is concluded that these bands represent different forms of angiotensinogen because the specific Ang I content is equivalent to the theoretical Ang I content. Analysis of the purified angiotensinogen showed it to contain 14% carbohydrate.

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Amino Acid Sequence Amino Acids Angiotensinogen Angiotensins Animals Electrophoresis, Polyacrylamide Gel Female Humans Hypertension Molecular Weight Pregnancy Pregnancy Complications, Cardiovascular Rats Species Specificity Swine Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

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D A Tewksbury. 1983. Angiotensinogen.. https://pubmed.ncbi.nlm.nih.gov/6862036/

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