Complement receptor mediates enhanced flavivirus replication in macrophages.

M J Cardosa; J S Porterfield; S Gordon

doi:10.1084/jem.158.1.258

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Complement receptor mediates enhanced flavivirus replication in macrophages.

M J Cardosa·J S Porterfield·S Gordon

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Abstract

Evidence is presented that M phi complement receptors (CR3) mediate IgM-dependent enhancement of flavivirus replication in the presence of complement. Enhancement is blocked by pretreatment of macrophages with monoclonal antibody Ml/70, which inhibits CR3 binding, but not by pretreatment with monoclonal antibody 2.4G2, which inhibits FcR binding.

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Animals Antibodies, Monoclonal Antibodies, Viral Cell Line Immunoglobulin M Macrophages Mice Receptors, Complement Virus Replication West Nile virus Journal Article Research Support, Non-U.S. Gov't

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M J Cardosa, J S Porterfield, S Gordon. 1983-07-01. Complement receptor mediates enhanced flavivirus replication in macrophages.. https://doi.org/10.1084/jem.158.1.258

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