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Lymphocyte abnormalities in the BB rat.

R Jackson·P Kadison·J Buse·N Rassi·B Jegasothy·G S Eisenbarth
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Abstract

The BB rat has a marked T cell lymphocytopenia, with a near absence of peripheral "helper" T cells recognized by monoclonal antibody W3/25 (W3/25+ T cells). The lymphocytes of the BB rat's spleen and thymus were examined for the presence of W3/25+ T cells, which were found to be absent in the spleen but present in normal amounts in the thymus. Concanavalin A (Con A) responsiveness was absent in the BB's peripheral blood and spleen but present in the thymus. Thus, in these three lymphoid compartments, Con A responsiveness directly correlated with the presence or absence of W3/25+ T cells. These lymphocyte abnormalities in the BB rat are notably different from lymphocyte changes present in human type I diabetes.

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AnimalsConcanavalin ALeukocyte CountLymphocyte ActivationLymphocytesLymphopeniaRatsRats, Inbred StrainsSpleenThymus GlandJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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R Jackson, P Kadison, J Buse, N Rassi, B Jegasothy, G S Eisenbarth. 1983. Lymphocyte abnormalities in the BB rat.. https://doi.org/10.1016/s0026-0495(83)80017-1

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