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Heteronomous DNA.

S Arnott·R Chandrasekaran·I H Hall·L C Puigjaner
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Abstract

A fibrous form of poly d(A):poly d(T) has a heteronomous secondary structure which is the first to be confirmed for a polynucleotide duplex: although both chains are 10(1) helices, mutually hydrogen-bonded in the standard (Watson-Crick) fashion, each has a quite different conformation. One chain -- probably poly d(A) -- has C3'-endo-puckered furanose rings characteristic of the A family of polynucleotide secondary structures while the other -- probably poly d(T) -- has the C2'-endo-puckered rings of the B family. Since analogous heteronomous structures could be assumed by DNA-DNA or DNA-RNA duplexes containing more general base sequences the polymorphic range of polynucleotide double-helices may be even greater than we have come to suppose.

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CrystallizationDNAMathematicsModels, MolecularNucleic Acid ConformationPoly dA-dTX-Ray DiffractionJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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S Arnott, R Chandrasekaran, I H Hall, L C Puigjaner. 1983-06-25. Heteronomous DNA.. https://doi.org/10.1093/nar%2F11.12.4141

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