[Negative feedback in the epiphyseal-thyroid system].

E S Rom-Bugoslavskaia; O Iu Honcharko

PubMed · 6866955

[Negative feedback in the epiphyseal-thyroid system].

Abstract

The negative feedback mechanism in the epiphyseal-thyroid system was studied. The activating thyroxin influence upon hydroxy-indole-O-methyl-transferase, being the main enzyme of melatonin biosynthesis, was found in experimental Wistar rats. The "dose-response" curves were examined at varying times after thyroxin injections. The results obtained confirm the previous data concerning the activating effect of rat chronic hyperthyroidization on hydroxy-indole-O-methyl-transferase and intensified melatonin excretion with the urine in patients with pronounced thyrotoxicosis.

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Acetylserotonin O-Methyltransferase Animals Dose-Response Relationship, Drug Feedback Male Melatonin Pineal Gland Rats Rats, Inbred Strains Thyroid Gland Thyroxine Time Factors English Abstract Journal Article

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E S Rom-Bugoslavskaia, O Iu Honcharko. [Negative feedback in the epiphyseal-thyroid system].. https://pubmed.ncbi.nlm.nih.gov/6866955/

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