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PubMed · 6880781

Methodological aspects of acute toxicity testing particularly LD50 determinations present use in development of new drugs.

J S Fowler·D A Rutty
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Abstract

It is essential to have an adequate understanding of the acute toxic effects of a new drug. It may not be necessary however to blindly follow the full classical median lethal assay on every occasion. The LD50 was developed to obtain the maximum accuracy from a modest experimental size. The objective of the study and the limitations of the assay should not be overlooked however and undue precision should not be sought. Methodological aspects including species and maximum and minimum doses will be discussed. Other methods and approaches to acute toxicity will be recommended with a more broad approach to acute toxicity than lethality alone.

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Animal HusbandryAnimalsAutopsyLethal Dose 50Pharmaceutical PreparationsResearch DesignSex FactorsSpecies SpecificityTime FactorsToxicologyJournal Article

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BibTeXRIS

J S Fowler, D A Rutty. 1983. Methodological aspects of acute toxicity testing particularly LD50 determinations present use in development of new drugs.. https://doi.org/10.1111/j.1600-0773.1983.tb02681.x

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