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PubMed · 688262

Steroid-nucleosides.

J E van Lier·G Kan·D Autenrieth·E Hulsinga
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Abstract

A new class of potential chemotherapeutic agents consisting of steroids coupled with nucleoside bases is described. Such structures may be viewed as nucleosides in which the sugar moiety is replaced by a steroid molecule. We may therefore expect the nucleoside characteristics to give interference at the DNA level, resulting in the desired antitumor activity, whereas the steroid moiety may provide target specificity. A number of such coupling products were prepared and preliminary biologic studies are reported.

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AnimalsAntineoplastic AgentsFemaleLeukemia L1210MiceNucleosidesRatsRats, Inbred F344Receptors, SteroidSteroidsJournal Article

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BibTeXRIS

J E van Lier, G Kan, D Autenrieth, E Hulsinga. 1978. Steroid-nucleosides.. https://pubmed.ncbi.nlm.nih.gov/688262/

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