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Steady-state distribution volume in physiologic multi-organ systems.

M Weiss
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Abstract

A unique definition of the apparent volume of distribution at steady-state is presented which is consistent with the realistic concept of blood concentration differences within the circulatory system. A physiologically based pharmacokinetic model consisting of eliminating and non-eliminating organs is used to predict the effect of drug elimination upon the steady-state distribution volume.

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HumansKineticsMetabolic Clearance RateModels, BiologicalPharmaceutical PreparationsJournal Article

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M Weiss. Steady-state distribution volume in physiologic multi-organ systems.. https://doi.org/10.1002/bdd.2510040207

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