Rapid corticosterone pulses.

R W Reynolds

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PubMed · 6887862

Rapid corticosterone pulses.

R W Reynolds

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Abstract

If micro-sampling techniques are used in conjunction with a highly sensitive radioimmunoassay procedure, it is possible to obtain repeated rapid measurements of plasma corticosterone concentrations from unanesthetized rats. Such a procedure reveals the existence of rapid corticosterone pulses with a duration of less than 60 s and amplitudes as great as 250 ng/ml. Several procedures were employed to determine that the pulses were not simply artifacts of the measurement and sampling methods. The existence of such rapid pulses provides for a duality of glucocorticoid function consisting of a rapid dynamic response capable of functioning simultaneously with, but independently of a slower long term regulatory response.

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Animals Corticosterone Kinetics Radioimmunoassay Rats Journal Article

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R W Reynolds. 1983. Rapid corticosterone pulses.. https://pubmed.ncbi.nlm.nih.gov/6887862/

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