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Immunologic tolerance and immunopathology.

W O Weigle
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Abstract

Immune tolerance has an antigen-directed specificity analogous to that of immune responsiveness. Studies have shown the direction of response-immunization or tolerization-is often dependent on the physical form and the dose of antigen, and that the two major lymphocyte classes, B cells and T cells, have different tolerance requirements. The critical relationships of these findings to autoimmunity are explored.

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AnimalsAntibodies, Anti-IdiotypicAntigensAutoantibodiesB-LymphocytesBone MarrowBone Marrow CellsCross ReactionsEpitopesImmune ToleranceImmunoglobulinsImmunosuppression TherapyLipopolysaccharidesMacrophagesMiceMice, Inbred NZBT-LymphocytesThyroglobulingamma-GlobulinsJournal Article

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W O Weigle. 1977. Immunologic tolerance and immunopathology.. https://doi.org/10.1080/21548331.1977.11707150

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