Randomized clinical trial.

C Kupfer

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PubMed · 6891416

Randomized clinical trial.

C Kupfer

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Abstract

The randomized clinical trial has a minimum of four elements. These are: 1. The use of control patients who either receive no treatment, the conventional treatment, or a placebo. 2. The use of random assignment of treatment to be tested. 3. The avoidance of investigator bias by single or double masking procedures. 4. The development of a sound ethical basis for the conduct of the research. These elements are discussed and the principles illustrated by a brief discussion of the diabetic retinopathy study conducted by the National Eye Institute.

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Clinical Trials as Topic Diabetic Retinopathy Double-Blind Method Ethics, Medical Follow-Up Studies Humans Laser Therapy Lasers Random Allocation Research Design Journal Article

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C Kupfer. 1982. Randomized clinical trial.. https://pubmed.ncbi.nlm.nih.gov/6891416/

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