Variable region (Fv) determinants on mouse lymphocytes.

I McConnell; P J Lachmann; D Givol

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PubMed · 68917

Variable region (Fv) determinants on mouse lymphocytes.

I McConnell·P J Lachmann·D Givol

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Abstract

Antisera have been raised to the Fv fragment derived from a mouse alpha/lambda myeloma. These had different reactivities for Fv and mouse immunoglobulin and two of them appeared to detect v region framework determinants on normal mouse immunoglobulins. A large proportion of mouse lymphocytes were shown to have Fv determinants on the surface which was part of the B-lymphocyte antigen receptor. Most of the reacting cells were B lymphocytes. Fv determinants were not detected on the majority of T lymphocytes including cells with known T-helper cell activity. It is concluded that in mice, T cells do not express immunoglobulin v region framework determinants on their surface.

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Animals B-Lymphocytes Binding Sites, Antibody Cell Membrane Epitopes Immunodiffusion Immunoelectrophoresis Immunoglobulin Variable Region In Vitro Techniques Lymphocytes Mice Journal Article

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I McConnell, P J Lachmann, D Givol. 1976. Variable region (Fv) determinants on mouse lymphocytes.. https://pubmed.ncbi.nlm.nih.gov/68917/

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