Kidney function and response to lithium treatment.

P Grof; M Hux; B Dressler; K O'Sullivan

doi:10.1016/s0278-5846(82)80136-x

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Kidney function and response to lithium treatment.

P Grof·M Hux·B Dressler·K O'Sullivan

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Abstract

1. Kidney function during long-term lithium treatment was studied in the representative sample of patients with recurrent affective disorders. Creatinine clearance, maximum urinary osmolality and 24-hour urine volume were determined. 2. Patients were divided according to their type of response to long-term lithium treatment, expressed by the effect on the frequency of recurrencies. Various indicators of kidney function were compared in excellent responders and in non-responders. 3. Long-term lithium treatment did not lead to any detectable changes of glomerular filtration in either group. 4. In comparison with responders, non-responders showed a significantly greater increase in 24-hour urine volume and a trend towards a greater reduction of maximum urinary osmolality, and thus a greater impairment of tubular function. 5. The findings stress the need for a careful selection of patients for long-term lithium stabilization.

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Bipolar Disorder Creatinine Glomerular Filtration Rate Humans Kidney Concentrating Ability Kidney Function Tests Lithium Middle Aged Recurrence Journal Article

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P Grof, M Hux, B Dressler, K O'Sullivan. 1982. Kidney function and response to lithium treatment.. https://doi.org/10.1016/s0278-5846(82)80136-x

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