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Ganglioside headgroup dynamics.

P M Lee·N V Ketis·K R Barber·C W Grant
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Abstract

Gangliosides, spin-labelled specifically on N-acetylneuraminic acid residues or on random-headgroup sugars, have been used to extend previous studies of headgroup behaviour. Headgroup sugar mobility is seen to be homogeneous and relatively unrestricted in a range of systems including three lines of cultured cells. The effects of temperature and pH have been considered. Binding of small quantities of the lectin, wheat germ agglutinin, was found to increase average headgroup mobility for gangliosides in lipid bilayers, most likely as a result of a disordering effect on ganglioside clusters.

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AnimalsCell LineChemical PhenomenaChemistryCricetinaeCricetulusFemaleGangliosidesHumansHydrogen-Ion ConcentrationLectinsLipid BilayersMusclesRatsSialic AcidsSpin LabelsThermodynamicsWheat Germ AgglutininsJournal ArticleResearch Support, Non-U.S. Gov't

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P M Lee, N V Ketis, K R Barber, C W Grant. 1980-09-18. Ganglioside headgroup dynamics.. https://doi.org/10.1016/0005-2736(80)90535-0

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