Does basic aluminum sucrose sulfate affect blood coagulability?

B F Mcgraw; E J Hesterlee; S L Gitomer; D H Hollander

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PubMed · 6893754

Does basic aluminum sucrose sulfate affect blood coagulability?

B F Mcgraw·E J Hesterlee·S L Gitomer·D H Hollander

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Abstract

Basic aluminum sucrose sulfate (sucralfate) is a sulfated disaccharide similar in structure to heparin that has been shown not to possess anticoagulant effects in vitro or in animal models. As an adjunct to a study of the efficacy of sucralfate in the treatment of duodenal ulcer disease, we evaluated the drug's anticoagulant effects. Twenty-eight patients were randimized to treatment with sucralfate. Evaluations of prothrombin time and activated partial thromboplastin time, prestudy and after two and/or four weeks of treatment with sucralfate, demonstrated no evidence of anticoagulant activity.

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Aluminum Anticoagulants Humans Partial Thromboplastin Time Prothrombin Time Sucralfate Sucrose Journal Article

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B F Mcgraw, E J Hesterlee, S L Gitomer, D H Hollander. 1980. Does basic aluminum sucrose sulfate affect blood coagulability?. https://pubmed.ncbi.nlm.nih.gov/6893754/

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