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DSIP-like immunoreactivity in the developing rat brain.

A J Kastin·C Nissen·D H Coy
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Abstract

Delta sleep-inducing peptide (DSIP) is a naturally occurring nonapeptide that has been reported to affect sleep. The concentration of DSIP-like material was measured by a highly specific radioimmunoassay in brain tissue from developing rats. DSIP-like immunoreactivity was present in fetal brain at increased levels shortly before birth. In one experiment, a significant elevation in the concentration of the peptide occurred at postnatal day 20, but in a second, similar, study the increase occurred later. No marked differences in the levels of DSIP-like immunoreactivity were found in the brains of rats injected 2 months earlier with DSIP or among 10 parts of brains obtained at postnatal day 20. Regardless of the function of DSIP, it is available to the rat throughout early development.

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Age FactorsAnimalsAnimals, NewbornBrainBrain ChemistryDelta Sleep-Inducing PeptideFemaleGestational AgeMaleOligopeptidesRatsRats, Inbred StrainsSex FactorsComparative StudyJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.

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A J Kastin, C Nissen, D H Coy. 1981. DSIP-like immunoreactivity in the developing rat brain.. https://doi.org/10.1016/0361-9230(81)90119-2

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