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The 'knotting' problem in proteins. Loop penetration.

M H Klapper·I Z Klapper
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Abstract

The 'knotting' problem in proteins is redefined in terms of the more general concept of loop penetration. Disulfide-containing proteins are represented as linear graphs, and it is proposed that proteins with nonplanar graph representations display loop penetrations in their three-dimensional structure. With this argument, it is shown that the occurrence of loop penetration in disulfide-containing proteins is approximately that expected based on the random pairing of sulfhydryl groups. It is argued that loop penetration is not as rare as currently held.

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DisulfidesModels, StructuralPancreatic ElastaseProtein ConformationProteinsJournal Article

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M H Klapper, I Z Klapper. 1980-11-20. The 'knotting' problem in proteins. Loop penetration.. https://doi.org/10.1016/0005-2795(80)90201-9

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