Reticuloendothelial cell dysfunction in diabetes and hyperlipidemia.

G Drivas; N Wardle

doi:10.1016/s0026-0495(78)80026-2

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Reticuloendothelial cell dysfunction in diabetes and hyperlipidemia.

G Drivas·N Wardle

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Abstract

Using clearances of microaggregated iodinated human serum albumin in a serial 'stress test,' defective phagocytosis by the Kupffer cells has been demonstrated in diabetic patients with K.W. nephropathy and proliferative retinopathy. This indicates a disturbance of phagocytic cell function that has implications for the cellular pathology of microangiopathy. The effect is not due to uremia, but could be due to T3 deficiency or lipid deposition. In hypothyroidism, there is defective RES phagocytosis, and alcoholics with hyperlipidemia can have impaired clearances. Hence, patients with advanced diabetes, hypothyroidism, and some alcoholics are at risk from infection.

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Diabetes Mellitus Diabetic Angiopathies Diabetic Nephropathies Diabetic Retinopathy Humans Hyperlipidemias Kupffer Cells Mononuclear Phagocyte System Phagocytosis Serum Albumin, Radio-Iodinated Journal Article

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G Drivas, N Wardle. 1978. Reticuloendothelial cell dysfunction in diabetes and hyperlipidemia.. https://doi.org/10.1016/s0026-0495(78)80026-2

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