Structure and function of major histocompatibility complex.

T J Gill

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PubMed · 6932830

Structure and function of major histocompatibility complex.

T J Gill

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Abstract

The major histocompatibility complex (MHC) contains genes that control the structure of many important cell surface antigens and influence a variety of important biological functions. The structures of the MHC in the human, rat and mouse show a remarkable similarity both in terms of the location of their genes and the chemical structures of the gene products. Thus, the region of the chromosome containing the MHC has been highly conserved during evolution, and this finding suggests that its genes are important for survival. Another set of genes, which influences growth and development, is linked to the MHC in the mouse (T/t complex) and in the rat (Grc): this entire chromosomal region may function as a "supergene" with broad effects on tissue organization and compatibility.

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Animals Biological Evolution Chromosome Mapping Genetic Markers H-2 Antigens HLA Antigens Histocompatibility Antigens Histocompatibility Antigens Class II Humans Major Histocompatibility Complex Mice Polymorphism, Genetic Rats Terminology as Topic Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

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T J Gill. 1980. Structure and function of major histocompatibility complex.. https://pubmed.ncbi.nlm.nih.gov/6932830/

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