PubMed · 6954662
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J Yata. 1982. [Immunologic deficiencies and abnormalities].. https://pubmed.ncbi.nlm.nih.gov/6954662/
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A consistent, planned approach to thymectomy for patients with myasthenia gravis has been used at the University of North Carolina since 1977. This involves a sternotomy, with excision of the entire thymus and adjacent fatty tissues from the thyroid to the diaphragm and laterally to 1 cm from each phrenic nerve. Between 1977 and 1993, 100 consecutive patients were treated in this manner with no mortality. Eight-four percent of patients were extubated in the operating room or within 1 hour of surgery, and no patients experienced postoperative respiratory difficulty. After a mean follow-up of 65 months, 78% of all patients improved by at least one modified Osserman classification, and 69% of patients with preoperative class I, II, or III disease (maximal preoperative severity) are in pharmacological remission. We conclude that transsternal thymectomy is associated with minimal morbidity and no mortality, and results in long-term improvement in symptoms for patients with myasthenia gravis.
Transcervical thymectomy is appropriate for managing carefully selected patients with myasthenia gravis due to its noninvasive nature, good cosmetic results, and favorable long-term outcomes. Contraindications to its use include the presence of a thymoma and advanced age. In optimally prepared patients, the operative complication rate is negligible and the average length of hospital stay is 1 to 2 days. The ultimate results of therapy often are not evident for several years postoperatively, indicating that comprehensive preoperative and postoperative treatment by a qualified neurologist is essential in optimizing outcomes. A meta-analysis of long-term results shows that 90% of patients who undergo the operation are improved, 80% become asymptomatic, and 50% achieve a complete remission.
The role of the glutamate receptor GluR3 in Rasmussen's encephalitis is actively under investigation. Autoimmune processes with this receptor as the target are currently theorized. We provide an additional case of pathologically proved Rasmussen's encephalitis (with concomitant cortical dysplasia) in the presence of antibodies against the GluR3 receptor.