PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 6956465

General and special educators' basic information and experience with cleft palate.

D E Finnegan
View original source ↗Export metadata ↓

Abstract

Two hundred and sixteen general and special educators completed a 25-item questionnaire which was designed to assess their knowledge of and experience with children with cleft palate. Special educators were found to be better informed and had more experience with these children than general educators. Both groups of educators, however, were deficient in basic information regarding cleft palate and associated problems, and acknowledged limited academic and classroom experience with this population. Yearly continuing education programs are essential for educators, because they are important members of the cleft palate child's habilitation team.

Explore related subjects

Cleft PalateEducation, SpecialFacultyHealth EducationHumansSurveys and QuestionnairesJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

D E Finnegan. 1982. General and special educators' basic information and experience with cleft palate.. https://pubmed.ncbi.nlm.nih.gov/6956465/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2024

Proteomic analysis illustrates the potential involvement of dysregulated ribosome-related pathways and disrupted metabolism during retinoic acid-induced cleft palate development.

Recent studies have unveiled disrupted metabolism in the progression of cleft palate (CP), a congenital anomaly characterized by defective fusion of facial structures. Nonetheless, the precise composition of this disrupted metabolism remains elusive, prompting us to identify these components and elucidate primary metabolic irregularities contributing to CP pathogenesis. We established a murine CP model by retinoic acid (RA) treatment and analyzed control and RA-treated embryonic palatal tissues by LC-MS-based proteomic approach. We identified 220 significantly upregulated and 224 significantly downregulated proteins. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis revealed that these differentially expressed proteins (DEPs) were involved in translation, ribosome assembly, mitochondrial function, mRNA binding, as well as key metabolic pathways like oxidative phosphorylation (OXPHOS), glycolysis/gluconeogenesis, and amino acid biosynthesis. These findings suggest that dysregulated ribosome-related pathways and disrupted metabolism play a critical role in CP development. Protein-protein interaction analysis using the STRING database revealed a tightly connected network of DEPs. Furthermore, we identified the top 10 hub proteins in CP using the Cytohubba plugin in Cytoscape. These hub proteins, including RPL8, RPS11, ALB, PA2G4, RPL23, RPS6, CCT7, EGFR, HSPD1, and RPS28, are potentially key regulators of CP pathogenesis. In conclusion, our comprehensive proteomic analysis provides insights into the molecular alterations associated with RA-induced CP in Kun Ming mice. These findings suggest potential therapeutic targets and pathways to understand and prevent congenital craniofacial anomalies.

Cleft Palate↗