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PubMed · 6956902

Common 82-nucleotide sequence unique to brain RNA.

J G Sutcliffe·R J Milner·F E Bloom·R A Lerner
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Abstract

Several randomly selected cDNA clones made from rat brain polyA+RNA have unusual properties. Although the cDNA inserts are 500-1,250 base pairs long, they hybridize to a 160-nucleotide RNA species that is present in brain but not in liver or kidney. Nucleotide sequence studies of two of the clones and hybridization studies show that a common 82-nucleotide sequence is responsible for the hybridization. The same sequence is located in the second intron of a rat growth hormone gene. These studies suggest that signals called "ID sequences" may be carried in the introns of genes and prescribe their tissue-specific expression.

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Base SequenceBrainCell DifferentiationDNAGene Expression RegulationNucleic Acid HybridizationRNA, MessengerJournal ArticleResearch Support, Non-U.S. Gov't

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J G Sutcliffe, R J Milner, F E Bloom, R A Lerner. 1982. Common 82-nucleotide sequence unique to brain RNA.. https://doi.org/10.1073/pnas.79.16.4942

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