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PubMed · 6963821

Iritis in leprosy.

T J Ffytche
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Abstract

Iritis in leprosy is still a significant cause of blindness and visual impairment in this disabling disease. Evidence is accumulating from clinical observations and from pathological and pharmacological studies that the chronic iritis of lepromatous leprosy may have a neuroparalytic origin. A hypothesis derived from this evidence is presented in order to stimulate further research into the pathogenesis of this condition with a view to developing new methods of management and prevention.

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Acute DiseaseChronic DiseaseHumansIritisLeprosyJournal ArticleResearch Support, Non-U.S. Gov't

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BibTeXRIS

T J Ffytche. 1981. Iritis in leprosy.. https://pubmed.ncbi.nlm.nih.gov/6963821/

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Acute spermatic cord torsion alters the microcirculation of the contralateral testis.

PURPOSE: The purpose of this study was to characterize the hemodynamic changes in the contralateral testis during acute spermatic cord torsion in anesthetized rats. MATERIALS AND METHODS: We used videomicroscopy to examine the microcirculation of the contralateral testis following acute torsion. Specifically, we examined the effect on vasomotion, a rhythmic dilation and constriction of the arterioles that is involved in fluid and nutrient exchange and modulation of local vascular resistance. In a separate set of experiments, blood flow in the contralateral internal spermatic artery was measured with an ultrasonic flow probe during acute torsion. RESULTS: Following 720 degrees torsion, the amplitude of vasomotion in the contralateral testis increased 121% (29.0 +/- 3.9% versus 13.0 +/- 1.7%) compared with controls. Blood flow in the contralateral internal spermatic artery decreased 43% after 2 hours' torsion. CONCLUSIONS: Acute spermatic cord torsion altered the microcirculation by increasing the amplitude of vasomotion and decreased total blood flow to the opposite testis. Because the hydraulic resistance of a blood vessel exhibiting vasomotion is always less than a vessel with the same average but static diameter, the observed microcirculatory changes may be an adaptive response to preserve local flow in the presence of decreased total flow. The long-term consequences of these changes in the microcirculation may affect testicular function and ultimately fertility.

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