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Mitogenic factor in human prostate extracts.

S C Jacobs·R K Lawson
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Abstract

Extracts of human benign prostatic hyperplasia, well-differentiated prostatic adenocarcinoma, and normal post-pubertal prostate stimulate 3H-thymidine incorporation by resting phase cultures of fetal rat osteoblasts and fibroblasts. The stimulation is concentration dependent and reaches a maximum at twenty-four hours of incubation. Prostatic extracts are also mitogenic in cell cultures of newborn human foreskin fibroblasts and the human cell lines, BUD-8 and DoT. The growth-stimulating factor is both heat and trypsin sensitive indicating that the factor is either a protein or contains a protein moiety. The growth-stimulating activity is not related to prostatic polyamine concentration. Experiments also show the activity is not due to human prostatic acid phosphatase. A prostatic growth factor may explain the growth of fibrous nodules in benign prostatic hyperplasia and the osteoblastic response of bone to prostatic cancer.

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Acid PhosphataseAdenocarcinomaAnimalsCells, CulturedDose-Response Relationship, DrugHumansHyperplasiaInterleukin-2LymphokinesMaleProstateProstatic NeoplasmsRatsTime FactorsJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.

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S C Jacobs, R K Lawson. 1980. Mitogenic factor in human prostate extracts.. https://doi.org/10.1016/0090-4295(80)90602-0

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