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Alkaline phosphatase positive lymphomas: a morphologic, immunologic, and enzymehistochemical study.

S Poppema·J D Elema·M R Halie
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Abstract

Among 87 cases of different non-Hodgkin lymphomas studied with morphologic, enzymehistochemical, and immunologic techniques, ten were found with a positive alkaline phosphatase staining reaction of the cell membranes. The ages of the seven adult patients included in this report varied between 48-85 years. Studies of cell suspensions or cryostat sections demonstrated the presence of monoclonal membrane immunoglobulins indicating a B-cell origin of these lymphomas. Investigation of peripheral blood of six patients revealed the presence of a corresponding monoclonal lymphocyte population in four. According to Rappaport's classification, lymphoblastic, poorly differentiated, and well-differentiated lymphocytic as well as histiocytic lymphoma were encountered. According to the "Kiel" classification, most lymphomas were classified in the group of follicle-center cell tumors. The clinical course of the patients was variable. Non-Hodgkin lymphomas with alkaline phosphatase positive staining do not constitute a separate entity.

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AgedAlkaline PhosphataseB-LymphocytesFemaleHistocytochemistryHumansLeukocytesLymph NodesLymphomaMaleMiddle AgedReceptors, Antigen, B-CellRosette FormationCase ReportsJournal ArticleResearch Support, Non-U.S. Gov't

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S Poppema, J D Elema, M R Halie. 1981-03-15. Alkaline phosphatase positive lymphomas: a morphologic, immunologic, and enzymehistochemical study.. https://doi.org/10.1002/1097-0142(19810315)47%3A6%3C1303%3A%3Aaid-cncr2820470612%3E3.0.co%3B2-s

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