Discrimination between self and nonself.

R G Miller

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PubMed · 6973385

Discrimination between self and nonself.

R G Miller

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Abstract

An hypothesis is presented that relates the ability of the immune system to distinguish between "self" and "nonself", the generation of diverse lymphocyte receptors and the role of the major histocompatibility complex. Experimental evidence supporting this hypothesis includes the recent discovery of a cell in the thymus that appears to inactivate thymus-derived lymphocytes reactive against self histocompatibility antigens.

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Animals HLA Antigens Humans Immune Tolerance Lymphocytes Mice Receptors, Immunologic T-Lymphocytes Thymus Gland Journal Article

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R G Miller. 1980-08-23. Discrimination between self and nonself.. https://pubmed.ncbi.nlm.nih.gov/6973385/

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