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PubMed · 6978073

Epithelioid granuloma formation requiring no T-cell function.

A Tanaka·K Emori·S Nagao·K Kushima·O Kohashi·M Saitoh·T Kataoka
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Abstract

Muramyl dipeptide (MDP), a minimal structure in bacterial cell walls essential for their adjuvant activity, was incorporated in a water-in-oil emulsion and injected into the footpads of nude rats devoid of functional T cells. MDP thus injected evoked massive epithelioid granulomas in the draining lymph nodes, indicating that MDP induced epithelioid granuloma formation requires no T cells. This finding with other data available strongly suggest that epithelioid granulomas can be induced without immunologic reactions.

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Acetylmuramyl-Alanyl-IsoglutamineAnimalsDNAFemaleGranulomaLymph NodesMaleNeutrophilsRatsT-LymphocytesJournal Article

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A Tanaka, K Emori, S Nagao, K Kushima, O Kohashi, M Saitoh, T Kataoka. 1982. Epithelioid granuloma formation requiring no T-cell function.. https://pubmed.ncbi.nlm.nih.gov/6978073/

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Acetylmuramyl-Alanyl-Isoglutamine↗
PubMed2007

NOD protein expression and function in first trimester trophoblast cells.

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