Primary structure of monkey osteocalcin.

P V Hauschka; S A Carr; K Biemann

doi:10.1021/bi00533a006

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Primary structure of monkey osteocalcin.

P V Hauschka·S A Carr·K Biemann

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Abstract

The complete 49-residue amino acid sequence of osteocalcin from the old world monkey Macaca fascicularis has been determined by efficient combination of gas chromatography-mass spectrometry and Edman techniques. This vitamin K dependent protein of bone matrix contains three gamma-carboxyglutamic acid residues at positions 17, 21, and 24, as well as a disulfide-bonded loop (23--29). Features of the sequence which apparently are required for the binding of Ca2+ have been strongly conserved throughout evolution.

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Amino Acid Sequence Animals Bone and Bones Calcium-Binding Proteins Gas Chromatography-Mass Spectrometry Humans Macaca fascicularis Osteocalcin Protein Conformation Species Specificity Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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P V Hauschka, S A Carr, K Biemann. 1982-02-16. Primary structure of monkey osteocalcin.. https://doi.org/10.1021/bi00533a006

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