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PubMed · 6979445

Circulating antigen-antibody complexes in onchocerciasis.

M W Steward·B Sisley·C D Mackenzie·H El Sheikh
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Abstract

The presence of circulating antigen-antibody complexes in the sera of patients with onchocerciasis was investigated using the Clq and conglutinin solid-phase binding assays. Only 50% of patients' sera had demonstrable complexes, levels of complexes were unrelated to microfilarial load and specific anti-onchocercal antibody titres and results with the two tests for complexes were not correlated. Both IgM- and IgG-containing complexes were commonly involved but there was no correlation between the levels of complexes containing these isotypes. Evidence for the presence of IgE in complexes of sera from a minority of individuals was also obtained.

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AntibodiesAntigen-Antibody ComplexComplement Activating EnzymesComplement C1qComplement Fixation TestsImmunoglobulin EImmunoglobulin GImmunoglobulin MMicrofilariaeOnchocercaOnchocerciasisSudanJournal ArticleResearch Support, Non-U.S. Gov't

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M W Steward, B Sisley, C D Mackenzie, H El Sheikh. 1982. Circulating antigen-antibody complexes in onchocerciasis.. https://pubmed.ncbi.nlm.nih.gov/6979445/

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