Multiple sclerosis: evidence for immunopathogenesis.

R P Lisak

doi:10.1212/wnl.30.7_part_2.99

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Multiple sclerosis: evidence for immunopathogenesis.

R P Lisak

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Abstract

I have attempted to review the evidence that one or more immunopathologic mechanisms are responsible for the clinical and pathologic findings in multiple sclerosis (MS). I believe that there is considerable evidence for an immunopathogenesis of MS, but it is not clear what type or types of reactions are involved or against which autoantigen, neoantigen, or microbial antigen the reaction is directed. In addition, there is growing evidence that there are abnormalities in immunologic control mechanisms in patients with MS, although whether these changes are a cause or a result of the disease is not clear.

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Animals Antibody-Dependent Cell Cytotoxicity Antigen-Antibody Complex Antigen-Antibody Reactions Binding Sites, Antibody Central Nervous System Encephalomyelitis Fluorescent Antibody Technique Guinea Pigs Humans Immunity, Cellular Immunoglobulin E Mice Multiple Sclerosis Rats Subacute Sclerosing Panencephalitis Journal Article Research Support, U.S. Gov't, P.H.S.Review

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R P Lisak. 1980. Multiple sclerosis: evidence for immunopathogenesis.. https://doi.org/10.1212/wnl.30.7_part_2.99

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