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PubMed · 6994918

Schedule induction and overindulgence.

J L Falk·M Tang
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Abstract

An animal model of human alcoholism is presented in which animals maintain chronic overdrinking to the extent that they develop severe physical dependence. They can be induced to overdrink ethanol in situations where an alternative fluid is present as well, so that the overindulgence is elective. The environmental conditions that produce this result also can induce the overingestion of other substances, aggression, and hyperactivity. It would appear, then, that many kinds of seemingly excessive, maladaptive behavior in animals and humans can have similar environmental sources. Alcoholism may be viewed within a context of environmental conditions that can produce a variety of excesses.

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Alcohol DrinkingAlcoholismAnimalsBehavior, AnimalDisease Models, AnimalEthanolFoodHumansReinforcement ScheduleSubstance-Related DisordersWater-Electrolyte BalanceJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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BibTeXRIS

J L Falk, M Tang. 1980. Schedule induction and overindulgence.. https://doi.org/10.1111/j.1530-0277.1980.tb04812.x

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Excessive alcohol consumption is a major health and social issue in our society. Pharmacologic administration of the endocrine hormone fibroblast growth factor 21 (FGF21) suppresses alcohol consumption through actions in the brain in rodents, and genome-wide association studies have identified single nucleotide polymorphisms in genes involved with FGF21 signaling as being associated with increased alcohol consumption in humans. However, the neural circuit(s) through which FGF21 signals to suppress alcohol consumption are unknown, as are its effects on alcohol consumption in higher organisms. Here, we demonstrate that administration of an FGF21 analog to alcohol-preferring non-human primates reduces alcohol intake by 50%. Further, we reveal that FGF21 suppresses alcohol consumption through a projection-specific subpopulation of KLB-expressing neurons in the basolateral amygdala. Our results illustrate how FGF21 suppresses alcohol consumption through a specific population of neurons in the brain and demonstrate its therapeutic potential in non-human primate models of excessive alcohol consumption.

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