Differences in thymus-dependency among various T-cell functions.

Y Shimamoto; K Taniguchi; C Kubo; K Nomoto

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PubMed · 7000693

Differences in thymus-dependency among various T-cell functions.

Y Shimamoto·K Taniguchi·C Kubo·K Nomoto

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Abstract

Effects of thymectomy of various times after birth on cytotoxicity, delayed footpad reaction and antibody production were examined in 6 week old mice immunized intraperitoneally with chicken erythrocytes. Cytotoxicity and antibody production were abolished by thymectomy within 3 days after birth. Mice thymectomized at 5 days of age or later showed appreciable degrees of cytotoxicity and antibody production. On the other hand, a delayed footpad reaction could be elicited even in mice thymetocmized within 24 h after birth, although the degree of the reaction was reduced by such a treatment. Therefore, T cells responsible for delayed hypersensitivity were less thymus-dependent and required the presence of the thymus for a shorter period in their development that those responsible for cytotoxicity or antibody production.

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Animals Antibody Formation Antilymphocyte Serum Cyclophosphamide Cytotoxicity, Immunologic Dose-Response Relationship, Immunologic Hemolytic Plaque Technique Hypersensitivity, Delayed Immunoglobulin G Lymphocyte Activation Mice Neoplasms, Experimental T-Lymphocytes Thymectomy Time Factors Journal Article Research Support, Non-U.S. Gov't

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Y Shimamoto, K Taniguchi, C Kubo, K Nomoto. 1980. Differences in thymus-dependency among various T-cell functions.. https://pubmed.ncbi.nlm.nih.gov/7000693/

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