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PubMed · 7011300

Quantification of hyperbaric oxygen-induced toxicity utilizing a malarial system.

N J Rencricca·R M Coleman·M D Altschule·P P Faletra·A D Gray·P E Desrochers·M J Doyle
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Abstract

This study was undertaken in recognition of the need to develop quantitative systems to evaluate the toxicity associated with hyperbaric oxygen (HBO) exposure. Malaria-infected (P. berghei berghei) mice were briefly exposed to 100% oxygen at 3 ATA on day 10 of infection. At 25, 48, and 72 h thereafter, the levels of circulating erythrcytes and percent parasitized RBC were monitored and compared to those of infected non-exposed controls. The total erythrocyte counts of the infected HBO-exposed and non-exposed mice did not differ significantly. In contrast, percent parasitized cells in the oxygen-exposed mice were lowered to 55-60% control values at 24, 48, and 72 h. The mechanism of this difference needs further study, but we believe that P. berghei-infected erythrocytes are preferentially hemolyzed as a consequence of HBO exposure. this mode system is useful in the study of HBO-induced toxicity because of its high degree of selectivity and sensitivity and its amenability to strict quantification over a period of at least several days.

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AnimalsErythrocyte CountErythrocytesFemaleHyperbaric OxygenationMalariaMiceOxygenPlasmodium bergheiJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.

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N J Rencricca, R M Coleman, M D Altschule, P P Faletra, A D Gray, P E Desrochers, M J Doyle. 1981. Quantification of hyperbaric oxygen-induced toxicity utilizing a malarial system.. https://pubmed.ncbi.nlm.nih.gov/7011300/

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