Disulfiram-associated hypercholesterolemia.

E L Rogers; S M Naseem

doi:10.1111/j.1530-0277.1981.tb04868.x

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PubMed · 7013551

Disulfiram-associated hypercholesterolemia.

E L Rogers·S M Naseem

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Abstract

The rat model is used to verify disulfiram-associated hypercholesterolemia and to determine a mechanism of action. Administration of disulfiram 15 mg/kg/day for 3 wk is associated with a 25% increase in serum cholesterol which is reversible with discontinuance of the drug. The hypercholesterolemia is due in part to a fourfold increase in activity of hepatic HMG-CoA reductase, the rate-limiting step in cholesterol biosyntheses.

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Animals Cholesterol Cholesterol 7-alpha-Hydroxylase Disulfiram Hydroxymethylglutaryl CoA Reductases Hypercholesterolemia Male Microsomes, Liver Rats Time Factors Journal Article

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E L Rogers, S M Naseem. 1981. Disulfiram-associated hypercholesterolemia.. https://doi.org/10.1111/j.1530-0277.1981.tb04868.x

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